• 이화여자대학교 의과대학 박사(신경병리학)
• 이화여자대학교 의과대학 석사
• 이화여자대학교 의과대학 졸업

• 2020-현재  | 이화의료원 헬스케어시스템부장
• 2019-현재  | 이화여자대학 의과대학 신경과학교실 주임교수
• 2019-현재  | 이대목동병원 뇌과학연구소장
• 2014-현재  | 이대목동병원 신경과 과장
• 2014-현재  | 이대목동병원 신경과 교수
• 2014-2020  | 이대목동병원 임상시험센터장
• 2014-2019  | 이대목동병원 임상의학연구부장/임상시험센터장
• 2012-2013  | University College of London, National Hospital for Neurology and Neurosurgery, Dementia Research Center, Honorary Visiting Professor
• 2011-2012  | 이화의료원 운영 서울시 서남병원 신경과 과장 및 공공의료단 단장
• 2010-2011  | 서울시 서남병원 신경과 과장 및 공공의료단 단장역임
• 2008-2014  | 이대목동병원 신경과 부교수
• 2005-2008  | 이대목동병원 신경과 조교수
• 2004-2005  | 이대목동병원 신경과 임상강사(치매 및 노인신경학)
• 2003-2004  | University of California, San Franscisco, Alzheimer’s disease and Research Center, Visiting Instructor
• 2003  | UCLA, Alzheimer’s disease and Research Center, Pathology lab, visiting Instructor
• 2002-2003  | 이대목동병원 임상강사(치매클리닉/뇌졸중)
• 2001-2002  | 한국에자이제약회사 의학부 이사
• 2000-2001  | 삼성서울병원 신경과 전임의(치매/인지장애 및 행동신경학)
• 1996-2000  | 이대동대문병원 신경과 전공의
• 1994-1995  | 이대동대문병원 인턴

• 2019 | Journal of Clinical neurology, 전공의 우수논문상 (지도교수)
• 2018 | Asian Society for Dementia Best Presenter (아시아치매학회 최우수발표상)
• 2018 | 대한치매학회 춘계학술대회 우수발표상
• 2012 | 강서구국민건강보험관공단 감사패
• 2012 | 대한치매학회 우수논문상
• 2012 | 이화여자대학교 의과대학 행림교육자상 (최우수교육자상)
• 2011 | 서울시 서남병원장 감사패
• 2011 | 보건복지부장관 치매유공자 표창장
• 2009 | 대한치매학회 우수논문상

• (특허) 알츠하이머병 치매의 발병 위험성 예측을 위한 후성 유전학적 진단 키트 개발
• (특허) TNFRSF19 유전자의 DNA 메틸레이션 변화를 이용한 알츠하이머병 치매 조기진단 마커
• (특허) 알츠하이머병 치매 관련 유전자 바이오마커 및 이의 이용
• (특허) 알츠하이머병 치매 특이적 DNA 메틸레이션 마커 검출용 조성물 및 검출방법
• (특허) 알츠하이머병 경도인지장애의 진단 또는 알츠하이머병 치매로의 진행 위험성 예측 방법
• (특허) 알츠하이머병 치매 특이적 유전자 NHLRC4 및 이를 이용한 알츠하이머병 치매 예측
• (특허) 유전자 CpG 메틸화 변화를 이용한 알츠하이머병 치매 진단용 조성물 및 이의 이용
• (특허) 유전자의 DNA 메틸레이션 변화를 이용한 알츠하이머병 경도인지장애의 진단 마커
• (특허) 알츠하이머병 치매 조기 진단을 위한 후성 유전학적 진단 키트 개발
• (특허) 알츠하이머병 치매 치료를 위한 분자 진단 테스트
• (특허) 피부 세포에서 IDE 유전자 프로모터의 CpG 메틸화 변화를 이용한 알츠하이머 질환 진단용 조성물 및 이의 이용
• (특허) 상호작용 가능한 블록 도구
• (특허) 체감형 인터랙티브 콘텐츠를 제공하기 위한 도구 및 그 방법
• (특허) 피부 세포에서 IDE 유전자 프로모터의 CpG 메틸화 변화를 이용한 알츠하이머 질환 진단용 조성물 및 이의 이용
• (특허) 퇴행성 질환의 조기 발견을 위한 언어능력진단 시스템, 방법 및 이를 제공하기 위한 컴퓨터 프로그램이 기록된 컴퓨터로 판독가능한 기록 매체
• (특허) 경도 인지 장애 및 알츠하이머성 치매 진단을 위한 문장 이해력 및 표현력 검사 장치 및 방법
• 2020-현재  | 대한인지중재치료학회 학술이사
• 2019-현재  | 게임포럼 이사
• 2018-현재  | 대한치매협회 이사
• 2018-현재  | 대한치매학회 국제이사
• 2015-현재  | 한국보건의료연구원 신의료기술평가 위원
• 2015-현재  | 한국보건의료연구원 신의료기술평가 위원
• 2011-현재  | Journal of Clinical Neurology Editor, 치매분야 전문위원
• 2009-현재  | 강서구치매센터 센터장
• 2018-2020  | 대한인지중재치료학회 교육이사
• 2018-2020  | 대한신경과학회 치매대책 특임이사
• 2017-2020  | 대한신경과학회 국문학회지 편집부위원장 역임
• 2017-2019  | 보건복지부/과학기술정보통신부 국가치매연구개발위원회 돌봄분과위원
• 2015-2016  | 미래창조과학부 뇌연구 실무추진위원회 연구위원
• 2015-2016  | 한국보건의료연구원 뇌연구자문위원
• 2009-2010  | 보건복지부 국가치매관리사업추진위원
• 2008-2009  | 보건복지부 국가치매대책수립 위원
• 2006-2010  | 대한치매학회 학술이사

•  18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment.  Yonsei Medical Journal. 2022, v.63 no.3, 259-264. 
•  Association between sleep parameters and longitudinal shortening of telomere length.  Aging. 2022, v.14 no.7, 2930-2944. 
•  Association between sleep parameters and longitudinal smartening of telomere length.  AGING-US. 2022, v.14 no.7, 2930-2944. 
•  Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial.  Stroke. 2022, v.29 no.2, 698-709. 
•  Distinctive Temporal Trajectories of Alzheimer's Disease Biomarkers According to Sex and APOE Genotype: Importance of Striatal Amyloid.  FRONTIERS IN AGING NEUROSCIENCE. 2022, v.14, 829202. 
•  Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia.  FRONTIERS IN AGING NEUROSCIENCE. 2022, v.14, 892590. 
•  Impact of Multidomain Lifestyle Intervention on Cerebral Cortical Thickness and Serum Brain-Derived Neurotrophic Factor: the SUPERBRAIN Exploratory Sub-study.  NEUROTHERAPEUTICS. 2022, v.19 no.5, 1514-1525. 
•  Impact of a multidomain lifestyle intervention on regional spontaneous brain activity.  FRONTIERS IN AGING NEUROSCIENCE. 2022, v.14, 926077. 
•  Non-transcription analysis of connected speech in mild cognitive impairment using an information unit scoring system.  Journal of Neurolinguistics. 2022, v.61, 101035. 
•  Predicting superagers by machine learning classification based on the functional brain connectome using resting-state functional magnetic resonance imaging.  Cerebral cortex (New York, N.Y. : 1991). 2022, v.32 no.19, 4183-4190. 
•  Prediction of conversion to dementia using interpretable machine learning in patients with amnestic mild cognitive impairment.  FRONTIERS IN AGING NEUROSCIENCE. 2022, v.14, 898940. 
•  Predictive Scale for Amyloid PET Positivity Based on Clinical and MRI Variables in Patients with Amnestic Mild Cognitive Impairment.  Journal of Clinical Medicine. 2022, v.11 no.12, 3433. 
•  Serum neurofilament light chain level as a predictor of cognitive stage transition.  Alzheimer's Research and Therapy. 2022, v.14 no.1, 6. 
•  Sex differences in the progression of cerebral microbleeds in patients with concomitant cerebral small vessel disease.  Frontiers in Neurology. 2022, v.13, 1054624. 
•  Subtle Cognitive Deficits Are Associated with Amyloid-β Positivity, but Not Severity of Self-Reported Decline: Results from the CoSCo Study.  Dementia and Geriatric Cognitive Disorders. 2022, v.51 no.2, 159-167. 
•  Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism.  Journal of Clinical Medicine. 2022, v.11 no.8, 2260. 
•  The Effect of Hearing Loss on Cognitive Function in Subjective Cognitive Decline.  DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2022, v.51 no.4, 348-356. 
•  The effects of 12-week mobile phone based cognitive intervention on brain function in patients with mild cognitive impairment.  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022, v.18, e065539. 
•  Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association with Alzheimer Disease-Related Phenotypes.  JAMA Network Open. 2022, v.5 no.12, E2247162. 
•  A Comparison of the Performance between the 60- and 120-Second Conditions of the Korean-Color Word Stroop Test: Color Reading (K-CWST: CR).  Dementia and Neurocognitive Disorders(대한치매학회지). 2021, v.20 no.4, 62-69. 
•  Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia.  Scientific Reports. 2021, v.11 no.1, 20598. 
•  Alzheimer’s cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans: CSF AD biomarkers measured by Lumipulse in Koreans.  Alzheimer's Research and Therapy. 2021 , 22. 
•  Asymmetric Amyloid Deposition as an Early Sign of Progression in Mild Cognitive Impairment Due to Alzheimer Disease.  Clinical Nuclear Medicine. 2021, v.46 no.7, 527-531. 
•  Cognitive trajectories of patients with focal ß-amyloid deposition.  Alzheimer's Research and Therapy. 2021, v.13 no.1, 48. 
•  Discontinuation rate of newly prescribed donepezil in alzheimer’s disease patients in asia.  Journal of Clinical Neurology (Korea). 2021, v.17 no.3, 376-384. 
•  Dual-phase F-18-florbetaben PET provides cerebral perfusion proxy along with beta-amyloid burden in Alzheimer's disease.  NEUROIMAGE-CLINICAL. 2021, v.31, 102773. 
•  Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer’s disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial.  Alzheimer's Research and Therapy. 2021, v.13 no.1, 66. 
•  Facility-Based and Home-Based Multidomain Interventions Including Cognitive Training, Exercise, Diet, Vascular Risk Management, and Motivation for Older Adults: A Randomized Controlled Feasibility Trial.  Aging. 2021, v.13 no.12, 15898-15916. 
•  Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population.  Alzheimer's Research and Therapy. 2021, v.13 no.1, 117. 
•  Impact of an education program for caregivers of patients with Alzheimer’s disease on treatment discontinuation and compliance in Korea.  Journal of Clinical Neurology (Korea). 2021, v.17 no.3, 368-375. 
•  Improvement in distinct cognitive functions between tablet PC and workbook in the SUPERBRAIN study.  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021, v.17, e054488. 
•  Increased telomere length in patients with frontotemporal dementia syndrome.  Journal of the Neurological Sciences. 2021, v.428, 117565. 
•  Language treatment effects on communicative abilities and working memory in Korean-speaking agrammatic Broca's aphasia caused by moyamoya disease: Phase II evidence from a case study.  NEUROCASE. 2021, v.27 no.3, 297-307. 
•  MIND 식단교육을 이용한 치매예방 영양프로그램이 고위험 치매노인의 인지기능 변화에 미치는 영향.  대한영양사협회 학술지. 2021, v.27 no.4, 248-262. 
•  Microbiota dysbiosis and functional outcome in acute ischemic stroke patients.  Scientific Reports. 2021, v.11 no.1, 10977. 
•  Novel Alzheimer’s disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers.  Translational Psychiatry. 2021, v.11 no.1, 296. 
•  Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study.  JOURNAL OF ALZHEIMERS DISEASE. 2021, v.82 no.4, 1451-1460. 
•  SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN (SUPERBRAIN) showed improvement in cognitive function mostly in individuals with nutritional improvement: Sub-analysis of SUPERBRAIN results.  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021, v.17, e054727. 
•  The Moderating Role of Sleep Quality on the Association between Neuroticism and Frontal Executive Function in Older Adults.  Behavioral Sleep Medicine. 2021, FEB 2021. 
•  The effects of robot-based cognitive intervention on resting-state EEG in patients with mild Alzheimer's disease dementia.  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021, v.17, e057652. 
•  연결 발화에서 나타난 경도인지장애군의 언어적 특징 분석.  특수교육. 2021, v.20 no.4, 31-53. 
•  Balance and Mobility Performance Along the Alzheimer's Disease Spectrum.  Journal of Alzheimer's disease : JAD. 2020, v.73 no.2, 633-644. 
•  CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer's disease as an indicator of tau phosphorylation.  Alzheimer's Research and Therapy. 2020, v.12 no.1, 83. 
•  Clinical significance of focal ss-amyloid deposition measured by F-18-flutemetamol PET.  ALZHEIMERS RESEARCH & THERAPY. 2020, v.12 no.1, 6. 
•  Differential deficits of nouns and verbs in a generative naming task for individuals with mild cognitive impairment.  Communication Sciences and Disorders. 2020 , 50-62. 
•  Feasibility of a 12 Week Physical Intervention to Prevent Cognitive Decline and Disability in the At-Risk Elderly Population in Korea.  JOURNAL OF CLINICAL MEDICINE. 2020, v.9 no.10, 3135. 
•  Four-Week, Home-Based, Robot Cognitive Intervention for Patients with Mild Cognitive Impairment: a Pilot Randomized Controlled Trial.  Dementia and Neurocognitive Disorders(대한치매학회지). 2020, v.19 no.3, 96-107. 
•  Reliability and Validity of a Short Form of the Korean Dementia Screening Questionnaire-Cognition.  JOURNAL OF CLINICAL NEUROLOGY. 2020, v.16 no.1, 145-153. 
•  SWATH-MS analysis of cerebrospinal fluid to generate a robust battery of biomarkers for Alzheimer’s disease.  Scientific Reports. 2020, v.10 no.1, 7423. 
•  Self- and informant-reported cognitive functioning and awareness in subjective cognitive decline, mild cognitive impairment, and very mild Alzheimer disease.  International Journal of Geriatric Psychiatry. 2020, v.35 no.1, 91-98. 
•  Self- and informant-reported cognitive functioning and awareness in subjective cognitive decline, mild cognitive impairment, and very mild Alzheimer disease.  International Journal of Geriatric Psychiatry. 2020, v.35 no.1, 91-98. 
•  South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial.   2020-04. 
•  Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer's disease.   2020-03. 
•  암 환자에서 연수막 전이 진단표지자로서의 뇌척수액 CYFRA 21-1.   2019-05. 
•  APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE epsilon 4 on Alzheimer's Disease Risk in a Multiracial Sample.   2019-08. 
•  Observational Study of Clinical and Functional Progression Based on Initial Brain MRI Characteristics in Patients with Alzheimer's Disease.   2018-01. 
•  Clinical and Biomarker Characteristics According to Clinical Spectrum of Alzheimer's Disease (AD) in the Validation Cohort of Korean Brain Aging Study for the Early Diagnosis and Prediction of AD.   2019-03. 
•  A Multicenter, Randomized Clinical Trial to Assess the Efficacy of a Therapeutic Intervention Program for Caregivers of People with Dementia.   2019-04. 
•  A Comparative Evaluation of the KDSQ-C, AD8, and SMCQ as a Cognitive Screening Test to Be Used in National Medical Check-ups in Korea.   2019-04. 
•  Blood amyloid- oligomerization associated with neurodegeneration of Alzheimer's disease.   2019-05. 
•  Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease.   2019-07. 
•  Clustering and Switching Patterns in Semantic Fluency and Their Relationship to Working Memory in Mild Cognitive Impairment.   2019-06. 
•  Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment.   2019-06. 
•  Self- and informant-reported cognitive functioning and awareness in subjective cognitive decline, mild cognitive impairment, and very mild Alzheimer disease.   2020-01. 
•  Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea.   2017-01. 
•  Anosognosia and Its Relation to Psychiatric Symptoms in Early-Onset Alzheimer Disease.   2017-05. 
•  Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study.   2017-01. 
•  PSEN1 p. Thr116Ile Variant in Two Korean Families with Young Onset Alzheimer's Disease.   2018-09. 
•  Predictors of Institutionalization in Patients with Alzheimer's Disease in South Korea.   2018-04. 
•  Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data.   2018-07. 
•  Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study.   2018-01. 
•  Effectiveness of Anti-Dementia Drugs in Extremely Severe Alzheimer's Disease: A 12-Week, Multicenter, Randomized, Single-Blind Study.   2018-01. 
•  Analysis of frontotemporal dementia, amyotrophic lateral sclerosis, and other dementia-related genes in 107 Korean patients with frontotemporal dementia.   2018-12. 
•  A genetic screen of the mutations in the Korean patients with early-onset Alzheimer's disease.   2016-11. 
•  Prognosis of Patients with Behavioral Variant Frontotemporal Dementia Who have Focal Versus Diffuse Frontal Atrophy.   2017-07. 
•  Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes.   2017-01. 
•  Effect of Individual and District-level Socioeconomic Disparities on Cognitive Decline in Community-dwelling Elderly in Seoul.   2017-09. 
•  Diagnostic and prognostic values of cerebrospinal fluid CYFRA 21-1 in patients with leptomeningeal carcinomatosis.   2017-08. 
•  알츠하이머병과 피질하혈관치매의 언어유창성검사수행능력 차이: 노인성치매임상연구센터 연구.   2016-02. 
•  The Effect of Processing Load on Semantic and Phonological Working Memory in Mild Cognitive Impairment.   2016-06. 
•  Encephalopathy in an Elderly Patient Following Oral Ingestion of Topical Methyl Salicylate.   2016-06. 
•  Effects of Ganglioside on Working Memory and the Default Mode Network in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial.   2016-04. 
•  Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort.   2016-09. 
•  Recent Updates of Therapeutic Intervention Programs for Caregivers of Patient with Dementia: Proposal of Hospital-Based Individual Therapy.   2016-06. 
•  Amyloid Beta-Mediated Hypomethylation of Heme Oxygenase 1 Correlates with Cognitive Impairment in Alzheimer's Disease.   2016-04. 
•  Higher Physical Activity Is Associated with Increased Attentional Network Connectivity in the Healthy Elderly.   2016-08. 
•  Effects of working memory treatment using verb-carrier phrases on language processing in persons with mild cognitive impairment.   2016-09. 
•  Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: vascular depression construct.   2016-07. 
•  Group- and Home-Based Cognitive Intervention for Patients with Mild Cognitive Impairment: A Randomized Controlled Trial.   2016-01. 
•  The effects of semantic feature analysis treatment on naming performance in Korean individuals with early dementia of the Alzheimer's type: Using a familiarity of nouns scale.   2015-03. 
•  Elevation of the Plasma A beta(40)/A beta(42) Ratio as a Diagnostic Marker of Sporadic Early-Onset Alzheimer's Disease.   2015-01. 
•  Reduced Gray Matter Density in the Posterior Cerebellum of Patients with Panic Disorder : A Voxel-Based Morphometry Study.   2015-02. 
•  Normative Study of the Literacy Independent Cognitive Assessment in Illiterate and Literate Elderly Koreans.   2015-07. 
•  Hippocampal volume and shape in pure subcortical vascular dementia.   2015-01. 
•  The Effects of Galantamine Treatment on Attention and Its Relationship with Cognition and Activities of Daily Living in Patients with Mild to Moderate Alzheimer's Disease?.   2015-01. 
•  Body Mass Index and Mortality Rate in Korean Patients with Alzheimer's Disease.   2015-01. 
•  Structural Brain Changes after Traditional and Robot-Assisted Multi-Domain Cognitive Training in Community-Dwelling Healthy Elderly.   2015-04. 
•  Clinical evolution, neuroimaging, and volumetric analysis of a patient with a CSF1R mutation who presented with progressive nonfluent aphasia.   2015-07. 
•  Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study.   2015-10. 
•  Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS).   2015-01. 
•  Literacy Independent Cognitive Assessment: Assessing Mild Cognitive Impairment in Older Adults with Low Literacy Skills.   2015-07. 
•  The Heterogeneity and Natural History of Mild Cognitive Impairment of Visual Memory Predominant Type.   2015-01. 

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