의료진 소개
정지향 교수
신경과, 웰에이징센터, 뇌신경센터 관심의료진 등록전문 진료 분야
퇴행성뇌질환(치매), 기억력 및 인지기능장애, 언어장애, 행동장애, 치매예방 ※수요일 웰에이징센터 진료
진료 일정
학력사항
- 이화여자대학교 의과대학 박사(신경병리학)
- 이화여자대학교 의과대학 석사
- 이화여자대학교 의과대학 졸업
교육 및 연구경력
- 2020-현재 | 이화의료원 헬스케어시스템부장
- 2019-현재 | 이화여자대학 의과대학 신경과학교실 주임교수
- 2019-현재 | 이대목동병원 뇌과학연구소장
- 2014-현재 | 이대목동병원 신경과 과장
- 2014-현재 | 이대목동병원 신경과 교수
- 2014-2020 | 이대목동병원 임상시험센터장
- 2014-2019 | 이대목동병원 임상의학연구부장/임상시험센터장
- 2012-2013 | University College of London, National Hospital for Neurology and Neurosurgery, Dementia Research Center, Honorary Visiting Professor
- 2011-2012 | 이화의료원 운영 서울시 서남병원 신경과 과장 및 공공의료단 단장
- 2010-2011 | 서울시 서남병원 신경과 과장 및 공공의료단 단장역임
- 2008-2014 | 이대목동병원 신경과 부교수
- 2005-2008 | 이대목동병원 신경과 조교수
- 2004-2005 | 이대목동병원 신경과 임상강사(치매 및 노인신경학)
- 2003-2004 | University of California, San Franscisco, Alzheimer’s disease and Research Center, Visiting Instructor
- 2003 | UCLA, Alzheimer’s disease and Research Center, Pathology lab, visiting Instructor
- 2002-2003 | 이대목동병원 임상강사(치매클리닉/뇌졸중)
- 2001-2002 | 한국에자이제약회사 의학부 이사
- 2000-2001 | 삼성서울병원 신경과 전임의(치매/인지장애 및 행동신경학)
- 1996-2000 | 이대동대문병원 신경과 전공의
- 1994-1995 | 이대동대문병원 인턴
수상경력
- 2019 | Journal of Clinical neurology, 전공의 우수논문상 (지도교수)
- 2018 | Asian Society for Dementia Best Presenter (아시아치매학회 최우수발표상)
- 2018 | 대한치매학회 춘계학술대회 우수발표상
- 2012 | 강서구국민건강보험관공단 감사패
- 2012 | 대한치매학회 우수논문상
- 2012 | 이화여자대학교 의과대학 행림교육자상 (최우수교육자상)
- 2011 | 서울시 서남병원장 감사패
- 2011 | 보건복지부장관 치매유공자 표창장
- 2009 | 대한치매학회 우수논문상
기타 학술 관련 경력
- (특허) 알츠하이머병 치매의 발병 위험성 예측을 위한 후성 유전학적 진단 키트 개발
- (특허) TNFRSF19 유전자의 DNA 메틸레이션 변화를 이용한 알츠하이머병 치매 조기진단 마커
- (특허) 알츠하이머병 치매 관련 유전자 바이오마커 및 이의 이용
- (특허) 알츠하이머병 치매 특이적 DNA 메틸레이션 마커 검출용 조성물 및 검출방법
- (특허) 알츠하이머병 경도인지장애의 진단 또는 알츠하이머병 치매로의 진행 위험성 예측 방법
- (특허) 알츠하이머병 치매 특이적 유전자 NHLRC4 및 이를 이용한 알츠하이머병 치매 예측
- (특허) 유전자 CpG 메틸화 변화를 이용한 알츠하이머병 치매 진단용 조성물 및 이의 이용
- (특허) 유전자의 DNA 메틸레이션 변화를 이용한 알츠하이머병 경도인지장애의 진단 마커
- (특허) 알츠하이머병 치매 조기 진단을 위한 후성 유전학적 진단 키트 개발
- (특허) 알츠하이머병 치매 치료를 위한 분자 진단 테스트
- (특허) 피부 세포에서 IDE 유전자 프로모터의 CpG 메틸화 변화를 이용한 알츠하이머 질환 진단용 조성물 및 이의 이용
- (특허) 상호작용 가능한 블록 도구
- (특허) 체감형 인터랙티브 콘텐츠를 제공하기 위한 도구 및 그 방법
- (특허) 피부 세포에서 IDE 유전자 프로모터의 CpG 메틸화 변화를 이용한 알츠하이머 질환 진단용 조성물 및 이의 이용
- (특허) 퇴행성 질환의 조기 발견을 위한 언어능력진단 시스템, 방법 및 이를 제공하기 위한 컴퓨터 프로그램이 기록된 컴퓨터로 판독가능한 기록 매체
- (특허) 경도 인지 장애 및 알츠하이머성 치매 진단을 위한 문장 이해력 및 표현력 검사 장치 및 방법
- 2020-현재 | 대한인지중재치료학회 학술이사
- 2019-현재 | 게임포럼 이사
- 2018-현재 | 대한치매협회 이사
- 2018-현재 | 대한치매학회 국제이사
- 2015-현재 | 한국보건의료연구원 신의료기술평가 위원
- 2015-현재 | 한국보건의료연구원 신의료기술평가 위원
- 2011-현재 | Journal of Clinical Neurology Editor, 치매분야 전문위원
- 2009-현재 | 강서구치매센터 센터장
- 2018-2020 | 대한인지중재치료학회 교육이사
- 2018-2020 | 대한신경과학회 치매대책 특임이사
- 2017-2020 | 대한신경과학회 국문학회지 편집부위원장 역임
- 2017-2019 | 보건복지부/과학기술정보통신부 국가치매연구개발위원회 돌봄분과위원
- 2015-2016 | 미래창조과학부 뇌연구 실무추진위원회 연구위원
- 2015-2016 | 한국보건의료연구원 뇌연구자문위원
- 2009-2010 | 보건복지부 국가치매관리사업추진위원
- 2008-2009 | 보건복지부 국가치매대책수립 위원
- 2006-2010 | 대한치매학회 학술이사
논문
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- Association between sleep parameters and longitudinal smartening of telomere length. AGING-US. 2022, v.14 no.7, 2930-2944.
- Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial. Stroke. 2022, v.29 no.2, 698-709.
- Distinctive Temporal Trajectories of Alzheimer's Disease Biomarkers According to Sex and APOE Genotype: Importance of Striatal Amyloid. FRONTIERS IN AGING NEUROSCIENCE. 2022, v.14, 829202.
- Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia. FRONTIERS IN AGING NEUROSCIENCE. 2022, v.14, 892590.
- Impact of Multidomain Lifestyle Intervention on Cerebral Cortical Thickness and Serum Brain-Derived Neurotrophic Factor: the SUPERBRAIN Exploratory Sub-study. NEUROTHERAPEUTICS. 2022, v.19 no.5, 1514-1525.
- Impact of a multidomain lifestyle intervention on regional spontaneous brain activity. FRONTIERS IN AGING NEUROSCIENCE. 2022, v.14, 926077.
- Non-transcription analysis of connected speech in mild cognitive impairment using an information unit scoring system. Journal of Neurolinguistics. 2022, v.61, 101035.
- Predicting superagers by machine learning classification based on the functional brain connectome using resting-state functional magnetic resonance imaging. Cerebral cortex (New York, N.Y. : 1991). 2022, v.32 no.19, 4183-4190.
- Prediction of conversion to dementia using interpretable machine learning in patients with amnestic mild cognitive impairment. FRONTIERS IN AGING NEUROSCIENCE. 2022, v.14, 898940.
- Predictive Scale for Amyloid PET Positivity Based on Clinical and MRI Variables in Patients with Amnestic Mild Cognitive Impairment. Journal of Clinical Medicine. 2022, v.11 no.12, 3433.
- Serum neurofilament light chain level as a predictor of cognitive stage transition. Alzheimer's Research and Therapy. 2022, v.14 no.1, 6.
- Sex differences in the progression of cerebral microbleeds in patients with concomitant cerebral small vessel disease. Frontiers in Neurology. 2022, v.13, 1054624.
- Subtle Cognitive Deficits Are Associated with Amyloid-β Positivity, but Not Severity of Self-Reported Decline: Results from the CoSCo Study. Dementia and Geriatric Cognitive Disorders. 2022, v.51 no.2, 159-167.
- Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism. Journal of Clinical Medicine. 2022, v.11 no.8, 2260.
- The Effect of Hearing Loss on Cognitive Function in Subjective Cognitive Decline. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2022, v.51 no.4, 348-356.
- The effects of 12-week mobile phone based cognitive intervention on brain function in patients with mild cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022, v.18, e065539.
- Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association with Alzheimer Disease-Related Phenotypes. JAMA Network Open. 2022, v.5 no.12, E2247162.
- A Comparison of the Performance between the 60- and 120-Second Conditions of the Korean-Color Word Stroop Test: Color Reading (K-CWST: CR). Dementia and Neurocognitive Disorders(대한치매학회지). 2021, v.20 no.4, 62-69.
- Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia. Scientific Reports. 2021, v.11 no.1, 20598.
- Alzheimer’s cerebrospinal biomarkers from Lumipulse fully automated immunoassay: concordance with amyloid-beta PET and manual immunoassay in Koreans: CSF AD biomarkers measured by Lumipulse in Koreans. Alzheimer's Research and Therapy. 2021 , 22.
- Asymmetric Amyloid Deposition as an Early Sign of Progression in Mild Cognitive Impairment Due to Alzheimer Disease. Clinical Nuclear Medicine. 2021, v.46 no.7, 527-531.
- Cognitive trajectories of patients with focal ß-amyloid deposition. Alzheimer's Research and Therapy. 2021, v.13 no.1, 48.
- Discontinuation rate of newly prescribed donepezil in alzheimer’s disease patients in asia. Journal of Clinical Neurology (Korea). 2021, v.17 no.3, 376-384.
- Dual-phase F-18-florbetaben PET provides cerebral perfusion proxy along with beta-amyloid burden in Alzheimer's disease. NEUROIMAGE-CLINICAL. 2021, v.31, 102773.
- Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer’s disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial. Alzheimer's Research and Therapy. 2021, v.13 no.1, 66.
- Facility-Based and Home-Based Multidomain Interventions Including Cognitive Training, Exercise, Diet, Vascular Risk Management, and Motivation for Older Adults: A Randomized Controlled Feasibility Trial. Aging. 2021, v.13 no.12, 15898-15916.
- Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population. Alzheimer's Research and Therapy. 2021, v.13 no.1, 117.
- Impact of an education program for caregivers of patients with Alzheimer’s disease on treatment discontinuation and compliance in Korea. Journal of Clinical Neurology (Korea). 2021, v.17 no.3, 368-375.
- Improvement in distinct cognitive functions between tablet PC and workbook in the SUPERBRAIN study. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021, v.17, e054488.
- Increased telomere length in patients with frontotemporal dementia syndrome. Journal of the Neurological Sciences. 2021, v.428, 117565.
- Language treatment effects on communicative abilities and working memory in Korean-speaking agrammatic Broca's aphasia caused by moyamoya disease: Phase II evidence from a case study. NEUROCASE. 2021, v.27 no.3, 297-307.
- MIND 식단교육을 이용한 치매예방 영양프로그램이 고위험 치매노인의 인지기능 변화에 미치는 영향. 대한영양사협회 학술지. 2021, v.27 no.4, 248-262.
- Microbiota dysbiosis and functional outcome in acute ischemic stroke patients. Scientific Reports. 2021, v.11 no.1, 10977.
- Novel Alzheimer’s disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers. Translational Psychiatry. 2021, v.11 no.1, 296.
- Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study. JOURNAL OF ALZHEIMERS DISEASE. 2021, v.82 no.4, 1451-1460.
- SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN (SUPERBRAIN) showed improvement in cognitive function mostly in individuals with nutritional improvement: Sub-analysis of SUPERBRAIN results. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021, v.17, e054727.
- The Moderating Role of Sleep Quality on the Association between Neuroticism and Frontal Executive Function in Older Adults. Behavioral Sleep Medicine. 2021, FEB 2021.
- The effects of robot-based cognitive intervention on resting-state EEG in patients with mild Alzheimer's disease dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021, v.17, e057652.
- 연결 발화에서 나타난 경도인지장애군의 언어적 특징 분석. 특수교육. 2021, v.20 no.4, 31-53.
- Balance and Mobility Performance Along the Alzheimer's Disease Spectrum. Journal of Alzheimer's disease : JAD. 2020, v.73 no.2, 633-644.
- CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer's disease as an indicator of tau phosphorylation. Alzheimer's Research and Therapy. 2020, v.12 no.1, 83.
- Clinical significance of focal ss-amyloid deposition measured by F-18-flutemetamol PET. ALZHEIMERS RESEARCH & THERAPY. 2020, v.12 no.1, 6.
- Differential deficits of nouns and verbs in a generative naming task for individuals with mild cognitive impairment. Communication Sciences and Disorders. 2020 , 50-62.
- Feasibility of a 12 Week Physical Intervention to Prevent Cognitive Decline and Disability in the At-Risk Elderly Population in Korea. JOURNAL OF CLINICAL MEDICINE. 2020, v.9 no.10, 3135.
- Four-Week, Home-Based, Robot Cognitive Intervention for Patients with Mild Cognitive Impairment: a Pilot Randomized Controlled Trial. Dementia and Neurocognitive Disorders(대한치매학회지). 2020, v.19 no.3, 96-107.
- Reliability and Validity of a Short Form of the Korean Dementia Screening Questionnaire-Cognition. JOURNAL OF CLINICAL NEUROLOGY. 2020, v.16 no.1, 145-153.
- SWATH-MS analysis of cerebrospinal fluid to generate a robust battery of biomarkers for Alzheimer’s disease. Scientific Reports. 2020, v.10 no.1, 7423.
- Self- and informant-reported cognitive functioning and awareness in subjective cognitive decline, mild cognitive impairment, and very mild Alzheimer disease. International Journal of Geriatric Psychiatry. 2020, v.35 no.1, 91-98.
- Self- and informant-reported cognitive functioning and awareness in subjective cognitive decline, mild cognitive impairment, and very mild Alzheimer disease. International Journal of Geriatric Psychiatry. 2020, v.35 no.1, 91-98.
- South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial. 2020-04.
- Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer's disease. 2020-03.
- 암 환자에서 연수막 전이 진단표지자로서의 뇌척수액 CYFRA 21-1. 2019-05.
- APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE epsilon 4 on Alzheimer's Disease Risk in a Multiracial Sample. 2019-08.
- Observational Study of Clinical and Functional Progression Based on Initial Brain MRI Characteristics in Patients with Alzheimer's Disease. 2018-01.
- Clinical and Biomarker Characteristics According to Clinical Spectrum of Alzheimer's Disease (AD) in the Validation Cohort of Korean Brain Aging Study for the Early Diagnosis and Prediction of AD. 2019-03.
- A Multicenter, Randomized Clinical Trial to Assess the Efficacy of a Therapeutic Intervention Program for Caregivers of People with Dementia. 2019-04.
- A Comparative Evaluation of the KDSQ-C, AD8, and SMCQ as a Cognitive Screening Test to Be Used in National Medical Check-ups in Korea. 2019-04.
- Blood amyloid- oligomerization associated with neurodegeneration of Alzheimer's disease. 2019-05.
- Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease. 2019-07.
- Clustering and Switching Patterns in Semantic Fluency and Their Relationship to Working Memory in Mild Cognitive Impairment. 2019-06.
- Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment. 2019-06.
- Self- and informant-reported cognitive functioning and awareness in subjective cognitive decline, mild cognitive impairment, and very mild Alzheimer disease. 2020-01.
- Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea. 2017-01.
- Anosognosia and Its Relation to Psychiatric Symptoms in Early-Onset Alzheimer Disease. 2017-05.
- Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study. 2017-01.
- PSEN1 p. Thr116Ile Variant in Two Korean Families with Young Onset Alzheimer's Disease. 2018-09.
- Predictors of Institutionalization in Patients with Alzheimer's Disease in South Korea. 2018-04.
- Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data. 2018-07.
- Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study. 2018-01.
- Effectiveness of Anti-Dementia Drugs in Extremely Severe Alzheimer's Disease: A 12-Week, Multicenter, Randomized, Single-Blind Study. 2018-01.
- Analysis of frontotemporal dementia, amyotrophic lateral sclerosis, and other dementia-related genes in 107 Korean patients with frontotemporal dementia. 2018-12.
- A genetic screen of the mutations in the Korean patients with early-onset Alzheimer's disease. 2016-11.
- Prognosis of Patients with Behavioral Variant Frontotemporal Dementia Who have Focal Versus Diffuse Frontal Atrophy. 2017-07.
- Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes. 2017-01.
- Effect of Individual and District-level Socioeconomic Disparities on Cognitive Decline in Community-dwelling Elderly in Seoul. 2017-09.
- Diagnostic and prognostic values of cerebrospinal fluid CYFRA 21-1 in patients with leptomeningeal carcinomatosis. 2017-08.
- 알츠하이머병과 피질하혈관치매의 언어유창성검사수행능력 차이: 노인성치매임상연구센터 연구. 2016-02.
- The Effect of Processing Load on Semantic and Phonological Working Memory in Mild Cognitive Impairment. 2016-06.
- Encephalopathy in an Elderly Patient Following Oral Ingestion of Topical Methyl Salicylate. 2016-06.
- Effects of Ganglioside on Working Memory and the Default Mode Network in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial. 2016-04.
- Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort. 2016-09.
- Recent Updates of Therapeutic Intervention Programs for Caregivers of Patient with Dementia: Proposal of Hospital-Based Individual Therapy. 2016-06.
- Amyloid Beta-Mediated Hypomethylation of Heme Oxygenase 1 Correlates with Cognitive Impairment in Alzheimer's Disease. 2016-04.
- Higher Physical Activity Is Associated with Increased Attentional Network Connectivity in the Healthy Elderly. 2016-08.
- Effects of working memory treatment using verb-carrier phrases on language processing in persons with mild cognitive impairment. 2016-09.
- Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: vascular depression construct. 2016-07.
- Group- and Home-Based Cognitive Intervention for Patients with Mild Cognitive Impairment: A Randomized Controlled Trial. 2016-01.
- The effects of semantic feature analysis treatment on naming performance in Korean individuals with early dementia of the Alzheimer's type: Using a familiarity of nouns scale. 2015-03.
- Elevation of the Plasma A beta(40)/A beta(42) Ratio as a Diagnostic Marker of Sporadic Early-Onset Alzheimer's Disease. 2015-01.
- Reduced Gray Matter Density in the Posterior Cerebellum of Patients with Panic Disorder : A Voxel-Based Morphometry Study. 2015-02.
- Normative Study of the Literacy Independent Cognitive Assessment in Illiterate and Literate Elderly Koreans. 2015-07.
- Hippocampal volume and shape in pure subcortical vascular dementia. 2015-01.
- The Effects of Galantamine Treatment on Attention and Its Relationship with Cognition and Activities of Daily Living in Patients with Mild to Moderate Alzheimer's Disease?. 2015-01.
- Body Mass Index and Mortality Rate in Korean Patients with Alzheimer's Disease. 2015-01.
- Structural Brain Changes after Traditional and Robot-Assisted Multi-Domain Cognitive Training in Community-Dwelling Healthy Elderly. 2015-04.
- Clinical evolution, neuroimaging, and volumetric analysis of a patient with a CSF1R mutation who presented with progressive nonfluent aphasia. 2015-07.
- Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study. 2015-10.
- Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS). 2015-01.
- Literacy Independent Cognitive Assessment: Assessing Mild Cognitive Impairment in Older Adults with Low Literacy Skills. 2015-07.
- The Heterogeneity and Natural History of Mild Cognitive Impairment of Visual Memory Predominant Type. 2015-01.
언론 보도
- [이투데이] 정지향 치매학회 이사 “치매 신약 앞서 진단·비약물치료 급여화 필요” 2024-10-10
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- [조선일보] “유전자 검사 한 번에 치매 가능성 확인” 2024-01-10
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건강동영상
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